Toxicological pathways

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August undefined, 2024

Web15 hours ago · Three degradation pathways, chlorine substitution, chlorine and hydroxyl substitution, and dealkylation were proposed for DHHB transformation in the Cl + solar process. Both Quantitative structure-activity relationship and Aliivibrio fischeri toxicity tests demonstrated increased toxicity for the chlorinated TBPs. A risk assessment of the DHHB … WebJan 1, 2014 · Based on the respective National Academy of Sciences / NRC report (NRC, 2007), a change toward new approach methodologies (NAMs) away from traditional animal testing, which is based on mechanistic...

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WebMar 12, 2024 · During recent years, omics methods and bioinformatics have increasingly been employed in toxicology. Omics approaches are applied in toxicology to find … WebNov 24, 2014 · Pathway-based analysis of chemical effects opens numerous opportunities to apply non-traditional approaches for understanding the risks of chemical exposure. Similarities in molecular initiating events and key events that lead to toxicological outcomes provide a defensible framework for extrapolating chemical effects across species, even if … br 8 u solji

TOXICOKINETICS, SUSCEPTIBLE POPULATIONS, BIOMARKERS, …

WebJan 1, 2024 · Here, we describe a novel method to develop reliable and sensible AOPs that relies on chemical-gene interactions, toxicity pathways, molecular regulations, … WebFeb 8, 2024 · Based on published integration methods and publicly available data with a toxicological research question, we evaluate in case studies whether integration of previously separately analyzed multi-omics data improves the detection of a molecular response at the pathway level. WebMar 12, 2024 · Among omics approaches, the best-developed methods which have been used in toxicology, include transcriptomics, proteomics and metabolomics. In this chapter, the focus will be on these methods, outlining the recent methodological advances and examples of their applications in toxicity studies of chemicals of emerging concern. bra1210bk

Toxicologic Pathology - an overview ScienceDirect Topics

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WebThe OECD launched a new programme on the development of Adverse Outcome Pathways (AOP) in 2012. An AOP is an analytical construct that describes a sequential chain of … WebFeb 17, 2024 · A toxicity pathway is defined by the NRC as “a cellular response pathway that would result in an adverse health effect when sufficiently perturbed” (NRC 2007). In addition to the 2007 NRC report, legislation has been passed and a number of initiatives implemented, ... bra110kWebOct 4, 2013 · Adverse outcome pathways (AOPs) are novel tools in toxicology and human risk assessment with broad potential. AOPs are designed to provide a clear-cut mechanistic representation of critical toxicological effects that span over different layers of … br8 8je

"WebToxicological studies – Different types of studies fall under the category of toxicological studies, including acute toxicity studies, which look at short-term exposures, and chronic toxicity studies, which look at exposures over a long period of time. " - Toxicological pathways

Toxicological pathways

Adverse Outcome Pathway Database (AOP-DB) US EPA

Web2 days ago · In choosing a suitable method for toxicity prediction, the available data and desired toxicity endpoint are two essential factors to consider. ... and biological pathways as descriptors of compounds. Models trained on different combinations of the collected, compound-target, compound-interactor, and compound-pathway profiles, were used to ... WebApr 8, 2024 · The reaction sites and degradation pathways of SDBS during VUV/O 3 were determined and the toxicological properties of the intermediates were evaluated. Finally, the applicability of VUV/O 3 in the removal of anionic surfactants from real …

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WebMay 25, 2024 · Toxicity testing and regulation of advanced materials at the nanoscale, i.e. nanosafety, is challenged by the growing number of nanomaterials and their property variants requiring assessment for potential human health impacts. The existing animal-reliant toxicity testing tools are onerous in terms of time and resources and are less and … WebOct 19, 2024 · Adverse outcome pathways (AOPs) are a recent toxicological construct that connects, in a formalized, transparent and quality-controlled way, mechanistic information to apical endpoints for regulatory purposes. AOP links a molecular initiating event (MIE) to the adverse outcome (AO) via key events (KE), in a way specified by key event relationships …

Web1 day ago · The toxicity pathway underlying the adverse outcome of paraquat at different exposure levels is discussed in the following sections. 4.1. Induction of oxidative stress and activation of the antioxidant system. Different with the other chloroplast-originated H … WebNov 3, 2024 · Certain chemicals can activate various toxicity pathways inside living cells. This causes a disruption to normal biological processes, like breathing or digestion, which can lead to harmful health effects such as diseases like cancer.

WebThe ultimate goal of the project would be to mine the resulting data for association between and among the various domains and the known toxicological properties of the base set of chemicals in order to provide a structured strategy to identify potential toxicity pathways, and to prioritize chemicals them for subsequent testing based on that ... WebMar 12, 2024 · The adverse outcome pathway (AOP) framework uses a modular structure to organize existing knowledge concerning the linkage between a molecular-level …

WebJan 1, 2014 · of a PoT as distinct from, but complementary to, other toxicological pathway concepts such as mode of action (MoA). The workshop came up with a preliminary de …

Webpp. 904-956. Volume 50, Issue 7, October 2024. Special Issue: Proceedings of the STP 41st Annual Symposium: Toxicologic Pathology of the Hematopoietic System. pp. 836-897. … bra 102 zzzWebOct 6, 2024 · Prediction Models for Agonists and Antagonists of Molecular Initiation Events for Toxicity Pathways Using an Improved Deep-Learning-Based Quantitative Structure-Activity Relationship System Authors Yasunari Matsuzaka 1 2 , Shin Totoki 3 , Kentaro Handa 3 , Tetsuyoshi Shiota 3 , Kota Kurosaki 1 , Yoshihiro Uesawa 1 Affiliations bra-1279zjWebAug 1, 2024 · The spatiotemporal sequence of disturbing toxicity pathways and key events (KEs) were identified by upstream regulator analysis. The MOA framework was constructed by KEs in biological and chronological order. Results There were a total of 71 references showing the relationship between lead exposure and neurotoxicity, which contained 2331 … bra213p07 bra-1280zj-dm21WebMar 19, 2024 · Adverse outcome pathway is a conceptual tool that delineates the causal pathways of chemical toxicity. The goal of AOP is to accurately predict the toxicity of chemicals, by serving as an alternative to traditional chemical risk assessment. First introduced for ecological toxicity, AOP is now widely used in chemical assessments. bra-1618zj-6dWebChair of BioMolecular Sciences. Professor of Pharmacology and Environmental Toxicology. University of Mississippi. Dr. Willett's research interests include polycyclic aromatic … bra211p04WebDec 12, 2008 · As toxicity pathway circuitry becomes better understood over time, it will be possible to create computational systems biology models for expected dose-response relationships for each of the assays used for toxicity testing following similar principles. bra211p05