Small vcp/p97-interacting protein expression

Author: llbp

August undefined, 2024

Web@article{Akcan2024AnalysisOT, title={Analysis of the developmental expression of small VCP-interacting protein and its interaction with steroidogenic acute regulatory protein in Leydig cells.}, author={G{\"u}lben Akcan and Ebru Alimoğullari and Radwan Abu-Issa and Sevil Cayli}, journal={Reproductive biology}, year={2024} } Gülben ... WebSVIP → Small VCP/p97-interacting protein Gene name : SVIP Family name : SVIP Entry whose protein (s) existence is based on evidence at protein level. Show evidences Annotations in this section apply to all the isoforms if not specified otherwise. INTERACTIONS Interacts (via VIM motif) with VCP. • gold 1 ev UniProt GO MOLECULAR …

Q8NHG7 - UniProt

WebValosin-containing protein (VCP) or transitional endoplasmic reticulum ATPase (TER ATPase) also known as p97 in mammals and CDC48 in S. cerevisiae, is an enzyme that in humans is encoded by the VCP gene. The … WebNov 18, 2002 · A bacterial expression plasmid for N-terminally hexahistidine-tagged VCP/p97 (His-VCP/p97) was constructed by subcloning the full-length cDNA of rat … cucet notification 2022

Structure and expression of a novel compact myelin …

WebOct 11, 2013 · •This study provides structural insight into interactions between SVIP and myelin membranes. -- Abstract: SVIP (small p97/VCP-interacting protein) was initially … WebUsing proteomic approaches, we identified VCP/p97 (valosin containing protein) as a novel neurofibromin interacting protein. The experiments combining cultured neurons and mouse genetic model suggest that VCP/p97 acts downstream of neurofibromin in controlling neuronal morphogenesis. Web(A) Protein groups identified from single motor neurons (MNs) and interneurons (INs). (B) Venn diagram indicating overlap of identified protein groups. (C) Principle component … marella cruise to malta

258010 - Gene ResultSVIP small VCP interacting protein [ (human)]

SVIP Is a Novel VCP/p97-interacting Protein Whose …

WebAug 31, 2011 · The small p97/VCP-interacting protein (SVIP) functions as an inhibitor of the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway. Here we show that overexpression of SVIP in... WebOct 11, 2013 · VCP, also named p97 or cdc48, executes diverse functions by association of this ATPase with over 40 different adaptor proteins (cofactors). These interactions typically depend on specific protein domains in both VCP and cofactors. marella cruise travel insuranceWebHere we find that compounds that activate the D1 ATPase activity of VCP/p97 fulfill these requirements. Such effects are seen with small molecule VCP activators like SMER28, which activate autophagosome biogenesis by enhancing interactions of PI3K complex components to increase PI(3)P production, and also accelerate VCP-dependent … marella cruise update

"WebMicroinjection of antibodies against Vcip135 and p47 in rat kidney cells showed that Vcip135 and p47 were required for Golgi and endoplasmic reticulum assembly. Wang et … " - Small vcp/p97-interacting protein expression

Small vcp/p97-interacting protein expression

SVIP Is a Novel VCP/p97-interacting Protein Whose Expression …

WebJan 18, 2024 · p97/VCP (CDC48p in yeast) is a highly abundant molecular chaperone that functions in diverse cellular processes such as ubiquitin-dependent proteolysis, retrograde transport of protein from... WebOct 11, 2013 · SVIP (small p97/VCP-interacting protein) was initially identified as one of many cofactors regulating the valosin containing protein (VCP), an AAA+ ATPase …

Did you know?

WebSmall p97/VCP-interacting protein (SVIP) was first discovered as one of the novel androgen-responsive genes as well as one of the many cofactors controlling p97/VCP. The aim of … WebTsujimoto Y, Tomita Y, Hoshida Y, et al. Elevated expression of valosin-containing protein (p97) is associated with poor prognosis of prostate cancer. Clin Cancer Res. 2004;10(9):3007–3012. 18. Cui Y, Niu M, Zhang X, Zhong Z, Wang J, Pang D. High expression of valosin-containing protein predicts poor prognosis in patients with breast …

WebWhile, VCP function was inhibited by small molecule VCP inhibitor Eeyarestatin I (EerI) [18] at a final concentration of 10 mM for 24 hrs and compared to DMSO control vehicle. The pcDNA3.1-VCP-myc and control plasmids were transfected as above for over expression experiments. Immunofluorescence Microscopy of Clinical Biopsies from NSCLC Patients- WebApr 11, 2024 · The mRNA expression levels of HRD1, gp78, E3 ligase enzymes; p97/VCP, retrotranslocation protein; UFD1L and NPL4, cofactor proteins; OS9, ER lectin protein and UFD2A which functions as ubiquitin-chain elongation factor E3/E4 ubiquitin ligase were significantly up-regulated by dexamethasone induction in a dose-dependent manner (Fig. …

WebEl gen SVIP (Small VCP/p97-Interacting Protein) codifica por una proteína que es un inhibidor de la degradación del retículo endoplasmático que también participa en la regulación de la autofagia y la vacuolización de las células. Su influencia en el metabolismo de las células cancerígenas, que ha sido recientemente descubierta, es un importante … WebJul 12, 2024 · possesses therapeutic potential. For example, valosin-containing protein (VCP/p97) is a hub protein that interacts with more than 30 adaptor proteins involved in various cellular functions. However, the role of each p97 PPI during the relevant cellular event is underexplored. The development of small-molecule PPI modulators remains …

WebAug 31, 2011 · The small p97/VCP-interacting protein (SVIP) functions as an inhibitor of the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway. Here we show that overexpression of SVIP in HeLa cells leads to localization of p97/VCP at the plasma membrane, intracellular foci and juxtanuclear vacuoles. marella delightWebJan 28, 2024 · The essential protein VCP/p97 regulates autophagosome formation by promoting the deubiquitinase activity of ataxin-3 toward Beclin-1 and also by regulating the assembly of the Beclin-1–PI3K ... cucei sede vallesWebMar 6, 2024 · Background: Endoplasmic reticulum-associated protein degradation (ERAD) eliminates misfolded proteins. Numerous illnesses, including cancer, cystic fibrosis, diabetes, and neurological diseases, are influenced by ERAD. ... Investigation of the effects of small VCP-interacting protein (SVIP) on the migration and invasion of breast cancer … marella cruise tuiWebAug 7, 2024 · The aim of the study was to investigate the expressions of SVIP, p97/VCP, StAR, CYP17A1 and 3β-HSD in human and mouse. Methods and results HLC, TM3 and MA … marella cubaWebNov 18, 2002 · A bacterial expression plasmid for N-terminally hexahistidine-tagged VCP/p97 (His-VCP/p97) was constructed by subcloning the full-length cDNA of rat VCP/p97 into pQE30 (QIAGEN). The bacterial expression plasmid for N-terminally hexahistidine-tagged Ufd1p (His-Ufd1p) was kindly donated by Dr. G. Warren. marella cruise tui loginWebproteins that interact speciﬁcally with VCP/p97 by using the yeast two-hybrid system, and discovered a novel VCP/p97-interacting protein named small VCP/p97-interacting protein (SVIP). Rat SVIP is a 76-amino acid protein that contains two putative coiled-coil regions, and potential myristoylation and palmitoylation sites at the N terminus. marella cruise tui contactWebDec 10, 2016 · This protein is a ubiquitin recognition factor protein which resides on the cytosolic side of ER membrane and forms a complex with the ubiquitin fusion degradation protein 1 (UFD1L, see below) and the valosin-containing protein (VCP, see below), also called p97 . A deficiency in any of the three members of the VCP/p97-UFD1L … cucet registration nta