Nettet1. jun. 2024 · OVX mice model. For OVX, mice were anesthetized with a mixture of medetomidine (0.3 mg/kg), midazolam (4 mg/kg), and butorphanol (5 mg/kg). … NettetIn ovariectomy (OVX) or orchiectomy (ORX) OP models, lumbar vertebrae are often used for evaluating of the OP progression. However, unlike the bipeds, the lumbar vertebrae are not weight loading bones in quadruped animal, but the head-bearing cervical vertebrae take much higher stress.
Transcriptome analysis of osteoblasts in an ovariectomized mouse …
Nettet1. jun. 2024 · OVX-induced osteoporosis mouse model. All animal experiments were approved by the Animal Ethics Committee of the Guangzhou University of Chinese Medicine (approved SYXK 2024-0202). Thirty 6-week-old female C57BL/6 mice were supplied by the Experiment Animal Center of the Guangzhou University of Chinese … NettetUnder general anesthesia, the mice were subjected to Sham surgery or bilateral surgical ovariectomy (OVX) by dorsal approach. 10 Bone loss was observed in them 2 months after OVX. Mice in the OVX+Veh or OVX + Ab group (n=5) were injected subcutaneously with saline or anti-Cxcl9 (R&D System, #AF-492-NA, 1μg/50 μL) every other day for 2 … jetdrive go toolbox
An In Vivo Estrogen Deficiency Mouse Model for Screening ... - JoVE
NettetThe ovariectomized (OVX) mouse is well suited for osteoporosis research, as shown to date by cross-sectional studies. Here, we investigate longitudinal changes by in vivo … NettetOur surgical services are conducted by highly skilled surgeons with vast experience in veterinary medicine and animal science and range from simple procedures (e.g., soft tissue/organ extractions) to highly … Nettet11. nov. 2024 · OVX of OA mice did not influence the cartilage phenotype or synovial thickness, while both cortical and trabecular subchondral bone mineral density (BMD) decreased after OVX compared with sham-operated mice at 8 weeks post-DMM surgery. Additionally, OVX mice displayed decreased motor activity, reduced threshold of pain … jet d\\u0027eau