Irf4 t cell

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August undefined, 2024

WebIRF4 from CD8+ T cells after their activation. We show that IRF4 is differentially required for long-term survival of CD8+ mem-ory T cell subsets. In particular, maintenance of tissue-resident memory T cells appears to depend on IRF4. Upon reactivation, IRF4-deficient CD8+ memory T cells are strongly impaired in theirproliferation andcytokine ... WebFeb 14, 2014 · The interferon regulatory factor 4 (IRF4) is an important immunological transcription factor required for B-cell maturation 3 and for the maintenance of various …

CD8 T细胞在感染过程中的转录和表观图谱 - 知乎

IRF4 is a transcription factor belonging to the Interferon Regulatory Factor (IRF) family of transcription factors. In contrast to some other IRF family members, IRF4 expression is not initiated by interferons; rather, IRF4 expression is promoted by a variety of bioactive stimuli, including antigen receptor engagement, lipopolysaccharide (LPS), IL-4, and CD40. IRF4 can function either as an activating or an inhibitory transcription factor depending on its transcription WebIrf4 is a critical regulator of many aspects of B- and T-cell differentiation and cell metabolism (Biswas et al., 2012; De Silva, Simonetti, Heise, & Klein, 2012; Eguchi et al., … irb tracking

IRF4 - an overview ScienceDirect Topics

WebApr 13, 2024 · Front. Cell. Dev. Biol. 2024, 9, 570451.（标注基金号81960239、82060244）论文3：Hua Fang#, Jianping Zhang* et al., Dexmedetomidine-up-regulated microRNA-381 exerts anti‐inflammatory effects in rats with cerebral ischaemic injury via the transcriptional factor IRF4. J. Cell. Mol. WebIRF4 Is Highly Induced in Graft-Infiltrating T Cells and Is Required for Heart Transplant Rejection IRF4 is a key transcription factor for translating TCR signaling into proper T cell responses ( Huber and Lohoff, 2014 ), but its role in T cell-mediated transplant rejection remains unclear. WebAug 1, 2024 · BATF-transduced CAR T cells exhibit enhanced tumor rejection. A preliminary screen for TFs that could enhance NFAT:AP-1 activity in CD8 + T cells led us to JUN, MAFF, and BATF (Extended Data Fig. 1), and raised the question whether JUN, MAFF, or BATF could confer a functional anti-tumor advantage on CD8 + CAR T cells in vivo.. CD8 + T cells … order authorizing motor vehicle sale

IRF4 at the crossroads of effector T‐cell fate decision ...

Frontiers Potential T Cell-Intrinsic Regulatory Roles for IRF5 via ...

WebT cell exhaustion during chronic infection was driven by high amounts of T cell receptor (TCR)-induced transcription factors IRF4, BATF, and NFATc1. These regulators … WebWe found that IRF4 was promptly induced in T cells upon TCR signaling through the MEK1/2 pathway. IRF4 ablation in T cells resulted in progressive establishment of CD4 + T cell dysfunction and induced heart allograft acceptance in mice. The dysfunctional state of Irf4 −/− T cells was initially reversible by blocking programmed death-ligand 1 (PD-L1) and … irb traductionWebMar 21, 2024 · IRF4 is a key regulator of mucosal IL-6 production in T cell-dependent experimental colitis and suggest that IRF4 might provide a therapeutic target for inflammatory bowel diseases. IRF-4 coordinates the two pathways regulating light-chain recombination by positioning pre-B cells away from IL-7-expressing stromal cells irb tracker

"Web研究结果. 1. cd8 t细胞在急性和慢性感染中经历了第一次分裂，表现出表型、转录和表观遗传的异质性. 为了比较cd8 t细胞对急性和慢性感染的反应，作者将具有识别lcmv免疫显性表位的t细胞受体(tcr)的cd8+cd45.1+ p14 t细胞转基因表达，随后过继转移到感染lcmv-arm的同源cd45.2+受体中。 " - Irf4 t cell

Irf4 t cell

WebJun 3, 2024 · Although the precise regulatory mechanisms at play for IRF4 in T cells have yet to be fully elucidated, levels of IRF4 have been shown to be higher in resting Th2 cells compared to Th1 and Th17 . Inquiries into the role of IRF5 in other immune cell types have revealed alternative roles for IRF4 outside that of direct transcriptional regulation. WebJan 19, 2024 · IRF4 was severely down-regulated in the colon cancer tissues. Colon cancer tissues exhibited an increase in the number of regulatory T cells (Tregs) and macrophages. Furthermore, IRF4 overexpression repressed proliferation, migration and invasion of colon cancer cells (SW480 and HT116 cells).

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WebMar 9, 2024 · The IRF4-deficient T cells exhibit reduced capacity to induce expansion of T-helper subsets that cause autoimmune disease, suggesting that an intrinsic function of … WebDec 19, 2024 · Tuning Irf4 Energizes Dysfunctional T Cells. The regulatory mechanisms governing T cell exhaustion remain incompletely understood. Man et al. (2024) and Wu et al. (2024) report that the T cell receptor responsive transcription factor Irf4 promotes T cell exhaustion in chronic viral infection but dampens exhaustion in response to tissue …

WebAug 12, 2024 · Earlier studies indicated that the ETS family transcription factor PU.1 and IRF4 are essential for T H 9 cell development 3, 4. Deficiency of PU.1 resulted in impaired T H 9 cell... WebSep 1, 2024 · Further analysis revealed cooperation between BATF and another transcription factor, interferon regulatory factor 4 (IRF4), to be vital for the exhaustion resistance phenotype, and CAR T cells expressing a BATF variant with lower affinity for IRF4 did not delay tumor growth or survive in tumors in mice.

WebWe found that IRF4 was promptly induced in T cells upon TCR signaling through the MEK1/2 pathway. IRF4 ablation in T cells resulted in progressive establishment of CD4 + T cell … WebSep 29, 2024 · Total human B cells from healthy donors were stimulated under conditions described in Figure 1A and analyzed by flow cytometry at days 3.5 and 6. Cells were pre-gated on FSC-A/FSC-W to identify singlets, on FSC-A/SSC-A to identify lymphocytes, and on IRF4/ Pax5 expression to identify the P1, P2, and P3 populations.

WebAug 13, 2024 · Interferon regulatory factor 4 (IRF4) is a lymphoid transcription factor and a key regulator in the development of various immune cells, including T and B cells. It is …

WebIRF4. Interferon regulatory factor 4 (IRF4) also known as MUM1 is a protein that in humans is encoded by the IRF4 gene, [5] [6] [7] located at 6p25-p23. IRF4 functions as a key regulatory transcription factor in the development of human immune cells. [8] [9] The expression of IRF4 is essential for the differentiation of T lymphocytes and B ... order authorizing sale of real propertyWebJan 20, 2024 · The transcription factor interferon regulatory factor 4 (IRF4) is critical for development of the immune system, especially B and T cells. The IRF4 International Consortium identified seven patients from six families with a combined immunodeficiency who harbored a recurrent heterozygous mutation in IRF4, p.T95R. order auralight.comWebAug 28, 2024 · Recurrent somatic mutations in host genes have exposed the T-cell receptor pathway through nuclear factor κB to interferon regulatory factor 4 (IRF4) as an essential … irb toll collectionWebIRF4 Is Highly Induced in Graft-Infiltrating T Cells and Is Required for Heart Transplant Rejection IRF4 is a key transcription factor for translating TCR signaling into proper T cell … irb trainedWebMar 29, 2024 · IRF4 on the other hand regulates cDC2 subsets, which express high levels of CD11b and CD172 in both mouse and humans and are highly efficient at inducing CD4 + T cell effector function and expansion. High expression of IRF8 in combination with E2-2 and Bcl11A are required for development of pDCs, which secrete high amounts of type I IFN in ... irb treatmentWebApr 14, 2024 · T cell exhaustion is an alternative differentiation path of T cells, sometimes described as a dysfunction. During the last decade, insights of T cell exhaustion acting as … irb town hallWebDec 7, 2024 · Roquin deficiency or IRF4 overexpression potently enhances anti-tumor immunity. These data provide a functional catalog of CD8 T cell fitness genes and suggest that targeting the Roquin-IRF4 axis is an effective strategy to enhance efficacy of adoptive transfer therapy for cancer. Graphical abstract View Large Image Download Hi-res image irb turnaround times