Inactivated sendai virus
WebSendai virus (SeV) is a non-segment negative-sense RNA virus that naturally infects and causes pneumonia in mice. As a prototypic member of the family Paramyxoviridae, SeV has been characterized well, and these studies revealed numerous traits of paramyxovirus biology. The reverse genetics system to rescue SeV was first established in 1995. WebFeb 23, 2024 · Inactivated Sendai virus particles eradicate tumors by inducing immune responses through blocking regulatory T cells. Cancer Res. 67 (1), 227–236. Article CAS PubMed Google Scholar Fujihara A., Kurooka M., Miki T., Kaneda Y. 2008. Intratumoral injection of inactivated Sendai virus particles elicits strong antitumor activity by …
Inactivated sendai virus
Did you know?
WebDec 1, 2014 · We previously reported that inactivated Sendai virus (hemagglutinating virus of Japan; HVJ) envelope (HVJ-E) activates anti-tumor immunity and induces cancer cell … WebOct 26, 2024 · Sendai virus (SeV), a prototype of the Paramyxoviridae family, binds to the host cell surface through its hemagglutinin-neuraminidase glycoprotein (HN). This binding also triggers the fusion protein (F), another envelope glycoprotein to undergo a conformational change and catalyze the mixing of viral and cellular lipid membranes ( …
WebApr 1, 1995 · Heat-inactivated Sendai virus can enter multiple MHC class I processing pathways and generate cytotoxic T lymphocyte responses in vivo We have earlier … WebMultinucleate cell formation induced by beta-propiolactone-inactivated Sendai virus in human fibroblast cells (a system in which fusion results from an interaction of the viral …
WebThe close apposition of infected and uninfected cells occurring during the agglutination pro- duced by treatment with ultraviolet-inactivated Sendai virus in the cold, rather than complete cell ... WebSendai virus was first isolated by Kuroya et al. (1953) in 1952 and was described clinically by Sano et al. (1953) and pathologically by Noda (1953) during an outbreak of …
WebJul 20, 2011 · We found that inactivated Sendai virus particle (HVJ-E) induced extensive cell death in the human glioblastoma cell line U251MG. Intradermal U251MG tumors were more effectively suppressed by HVJ-E ...
WebDec 4, 2024 · In recent years, inactivated Sendai virus particles (hemagglutinating virus of Japan envelope, HVJ-E) have been shown to contribute to several anti-cancer effects, … immigration courtsWebPreparation of Sendai Virus for Cell Fusion. Reet Tees, in Immunological Methods, 1979. V ASSAY OF INFECTIVITY. The inactivated virus is diluted in tenfold steps (10 −1 to 10 −6) in Earle's BSS and 0.05 ml of each dilution is inoculated allantoically into a group of three eggs (see Section I). After incubation at 35°C for 68–72 hr, about ... immigration courts budgetWebDec 4, 2024 · In recent years, inactivated Sendai virus particles (hemagglutinating virus of Japan envelope, HVJ-E) have been shown to contribute to several anti-cancer effects, such as the activation of anti-tumor immunity via anti-tumorigenic neutrophils in the tumor microenvironment , the suppression of murine melanoma growth by host immune … immigration court searchHVJ-E was manufactured at GenomIdea Inc. (Osaka, Japan). HVJ was irradiated by the treatment with β-propiolactone and ultraviolet irradiation, which caused the alkylation and the fragmentation of the RNA genome. HVJ-E was purified by four steps of column chromatography, stabilized by lyophilization and … See more This study was a single-arm, open-label, single-center, phase I/II study of HVJ-E in patients with CRPC who were docetaxel resistant or could not receive docetaxel treatments. The primary end points were to evaluate safety and … See more Eligible patients had to have CRPC and be docetaxel resistant or unable to receive docetaxel treatment and have a prostate in which HVJ-E could be administered. Patients were … See more Patients were monitored in hospital from day 1 to day 14 and at each outpatient visit on days 21 and 28 of each cycle. The National Cancer Institute’s Common Terminology Criteria for Adverse Events version 4.0 was used … See more A 3+3 design was used to determine the maximum tolerated dose of HVJ-E administration. HVJ-E was administered directly to the … See more list of tax credit apartmentsWebJul 20, 2011 · HVJ-E preparation and siRNA transfection: HVJ (VR-105 parainfluenza 1 Sendai/52, Z strain) propagated in HEK293 cells was collected and inactivated by UV … list of taxable fringe benefitsWebfrom publication: Enhancement of Sendai virus-mediated cell fusion by cupric ions The effect of divalent cations on cell fusion by concentrated Sendai virus, inactivated by beta-propiolactone ... list of tata products in marketWebJul 18, 2016 · Some studies [37–38] have found that UV-inactivated Sendai virus is different from a saline control, which is unable to replicate in cells because the genome is destroyed by UV irradiation, but still contains the complete structure of the live HVJ envelope containing F, HN, and M proteins. These proteins have displayed antitumor effect ... list of tax credits for 2021