Biological applications of ionophores

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August undefined, 2024

In chemistry, an ionophore (from Greek ion and -phore 'ion carrier') is a chemical species that reversibly binds ions. Many ionophores are lipid-soluble entities that transport ions across the cell membrane. Ionophores catalyze ion transport across hydrophobic membranes, such as liquid polymeric membranes (carrier-based ion selective electrodes) or lipid bilayers found in the living cells or synthetic vesicles (liposomes). Structurally, an ionophore contains a hydrophilic center … WebIonophores are compounds that form lipid soluble, dynamically reversible complexes with cations and by this means facilitate specific ionic transport across biologic membranes (Pressman, 1976; Reed, 1982; Taylor et al., 1982 ). There are two major subclasses of ionophores, (1) neutral ionophores, which are highly toxic because they form charged ...

Zinc ionophores: chemistry and biological applications - PubMed

WebMar 15, 2024 · As such, an essential part of all applications is a letter of sponsorship from the BSD faculty member with whom the applicant proposes to work, outlining the … WebPolyether ionophores are complex natural products capable of transporting cations across biological membranes. Many polyether ionophores possess potent antimicrobial activity and a few selected compounds have the ability to target aggressive cancer cells. Nevertheless, ionophore function is believed … bird scooters company website

Zinc ionophores: chemistry and biological applications

WebBiological applications of ionophores. by B C Pressman. Annual review of biochemistry. Read more related scholarly scientific articles and abstracts. WebNov 1, 2024 · Cu ionophores include HQs that have a vast variety of biological applications. The most known compound of the HQ class is 7-iodo-5-chloro-8-hydroxyquinoline (CQ) that was first used as an ... WebMay 30, 2013 · Moreover, the discovery of salinomycin and other natural ionophores as CSC-selective drugs opened up the possibility of repurposing these drugs for novel applications in human medicine ... danaher wonder what\\u0027s within

Biological activity of synthetic ionophores: ion transporters as ...

WebNatural compounds, which have evolved their function over millions of years, are often more efficient than man-made compounds if a specific biological activity is needed, e.g. as an enzyme inhibitor or as a toxin to … WebAnalogous ionophores have now been synthesized. Unique applications for these compounds are emerging, based either on their selective toxicity or ability to modify … bird scooters appleton wiWebThe structure and physical chemical properties are reviewed of various ionophores, small molecules which transport cations across biological membranes. The subclass of carboxylic ionophores has dramatic pharmacological properties, dilating the coronary arteries and increasing cardiac contractility, which make them especially interesting. danaher upper body takedowns

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Biological applications of ionophores

A Comparison of Neutral Mg2+-Selective Ionophores in Solvent …

WebMar 4, 2024 · The development of new therapeutic agents should aim to increase selectivity and therefore reduce side effects. In addition, these agents should overcome cancer cell resistance and target cancer ... WebBiological applications of ionophores. Pressman BC. Annual Review of Biochemistry , 01 Jan 1976, 45: 501-530 DOI: 10.1146 ... Biological applications and evolutionary origins of ionophores. Pressman BC, deGuzman NT. Adv Exp Med Biol, 84:285-300, 01 Jan 1977

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WebDec 21, 2024 · Zinc ionophores increase the intracellular concentration of Zinc ions causing significant biological effects. This review provides, for the first time, an overview of the … WebFeb 15, 2015 · 6 Structure and Biological Activity of Polyether Ionophores and Their. ... Practical applications The present study is the first to study the effect of M. longifolia in an experimental model of ...

WebMay 27, 2024 · Despite several ionophores revealing potential therapeutic applications as apoptosis inducers, ... In the context of transporting molecules of biological relevance, quite a few ionophores have been … WebNov 1, 2024 · Copper ionophores alter the concentration, distribution, and reactivity of endogenous copper ions with consequent profound biological repercussions. The …

WebApr 6, 2024 · Ionophores transport ions across biological membranes and have wide-ranging applications, but a platform for their rapid development does not exist. We report a platform for developing ionophores from metal-ion chelators, which are readily available with wide-ranging affinities and specificities, and structural data that can aid rational design. WebAs it has turned out, medical and pharmaceutical applications of ionophores are limited, since the activity of ionophores is not restricted to microbial membranes. On the other hand, ionophores were found to be wonderful tools in biochemical research at the cellular or membrane level. ... Pressman, B.C.: Biological applications of ionophores ...

WebPressman BC (1976) Biological applications of ionophores. Ann Rev Biochem 45:501–530. CrossRef PubMed CAS Google Scholar Puskin JS, Gunter TE (1975) Electron paramagnetic resonance of copper ion and manganese ion complexes with the ionophore A23187. Biochemistry 14:187–191 . CrossRef ...

WebJan 1, 2024 · Biological Applications of Ionophores. Article. Feb 1976; Berton C. Pressman; View. Effects of a low protein diet during pregnancy of the rhesus monkey. I. Reproductive efficiency. Article. bird scooter schematicWebJan 15, 2000 · Monopodal and oligopodal Mg2+-selective ionophores were characterized by their selectivity coefficients (Separate Solution Method, SSM) in plasticized poly ... “Chemical Sensors and Biosensors for Medical and Biological Applications”, 1998, Wiley–VCH, Weinheim. M. Müller, M. Rouilly, B. Rusterholz, M. Maj-Zurawska, Z. Hu, … bird scooters fort worthWebMay 27, 2024 · A comprehensive investigation of the structure-activity relationships, selectivity aspects and biological implications in terms of potential therapeutic applications of these ionophores will be … bird scooters contact infoWebAug 13, 2024 · Labile zinc, a tiny fraction of total intracellular zinc that is loosely bound to proteins and easily interchangeable, modulates the activity of numerous signaling and … danaher water spin offWebThe Hippo pathway was initially discovered in Drosophila melanogaster as a key regulator of tissue growth. It is an evolutionarily conserved signaling cascade regulating numerous … bird scooters cincinnatiWebJul 1, 1976 · Ionophores are compounds of moderate molecular weight (about 200-2(00) that form lipid-soluble complexes with polar cations, of which K+, Na+, Ca2+, Mg2+, and … bird scooters decorah iaWebMar 1, 2024 · Herein, the biological applications of Zn ionophores are reviewed, discussing the coordination chemistry, the mechanism of action, and interactions with target … bird scooters burlington iowa